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Localised buckling, writhing and cutting of the DNA molecule J. Michael T. Thompson FRS Department of Applied Mathematics and Theoretical Physics, Cambridge DNA and why it gets twisted Topology of writhing Topoisomerase: nature's cutting enzyme Mechanics of stretched and twisted rods Single-molecule magnetic tweezer experiment Mechanics of steady–state plying

DNA and why it gets twisted

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Topology of writhing

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The cutting enzyme (Topo = topoisomerase)

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Mechanics of stretched and twisted rods

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The magnetic tweezer experiment

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Mechanics of steady–state plying

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